Unit 7: Topical & Transdermal Systems
Topical and transdermal systems deliver drugs locally or systemically through the skin, offering targeted therapy and controlled release. Formulation involves selecting appropriate bases, penetration enhancers, and ensuring compliance with USP evaluation standards.
Definition
Topical dosage forms are applied to the skin or mucous membranes for local or systemic effects, while transdermal systems deliver drugs through the skin into systemic circulation.
These systems provide targeted therapy, avoid first-pass metabolism, and improve patient compliance. Formulation requires consideration of skin permeability, drug solubility, and excipient compatibility.
Key Points
Topical forms include ointments, creams, gels, and lotions
Transdermal patches provide controlled systemic delivery
USP standards apply for uniformity, content, and performance
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