Unit 3: Material Properties & Powder Flow
Material properties and powder flow studies ensure consistent manufacturing of solid dosage forms by evaluating density, compressibility, and flowability. Key parameters include Carr’s Index, Hausner Ratio, and angle of repose, which predict processing performance.
Definition
Material properties and powder flow characteristics are critical for ensuring uniformity, compressibility, and manufacturability of solid dosage forms.
Powder flow properties influence blending, granulation, and tablet compression. Poor flow can lead to weight variation, segregation, and process inefficiencies.
Key Points
Bulk and tapped density determine packing ability
Carr’s Index and Hausner Ratio indicate flowability
Angle of repose measures powder flow tendency
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