Unit 16: Drug Diffusion & Release Mechanism
Drug release mechanisms define how APIs are liberated from dosage forms, modeled by zero-order, first-order, Higuchi, and Korsmeyer-Peppas equations. Advanced models like Hixson-Crowell and Weibull enable prediction for complex controlled-release systems.
Definition
Drug release mechanisms describe how active pharmaceutical ingredients are liberated from dosage forms into the biological environment for absorption.
Understanding release kinetics is essential for designing controlled, sustained, and targeted drug delivery systems. Mathematical models predict release profiles and guide formulation optimization.
Key Points
Release mechanisms include diffusion, erosion, and osmotic control
Kinetic models describe drug release patterns
Advanced models enable prediction and customization of release profiles
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